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Investigative Protocols

Clinical Conditions

Female Infertility Evaluation of female infertility
Irregular Periods Evaluation of irregular periods
Female 1 Hormonal changes during menstrual cycle
Female 2 Hormonal changes during menstrual cycle
Prolactin High Causes of hyperprolactinaemia (prolactin > 700 mIU/L)

Coagulation Tests

Platelet Platelet function analysis
Thrombosis Risk factors for venous thromboembolism
vWF1 von Willebrand disease

Drug Screen Interpretation

Methadone Evaluation of EDDP (methadone metabolite) results
THC Evaluation of 9-tetrahydrocannabinol (THC) results
UDS Urine drug screening
UDS Amph Evalution of sympathomimetic amine results
UDS Benzo Evaluation of benzodiazepine results
UDS Cocaine Evaluation of cocaine results
UDS Opiate Evaluation of opiate results
UDS TLC Thin layer chromotography

Endocrine Tests

 
Cushings Evaluation of Cushing's syndrome - see flowchart
TSH High Evaluation of an elevated serum TSH (> 4.0 mU/L)
TSH Low Evaluation of a subnormal serum TSH (< 0.2 mU/L)

General Biochemistry

Bicarb Low Causes of low plasma bicarbonate (bicarbonate < 18)
Calcium High 1 Causes of hypercalcaemia (calcium > 2.6)
Calcium High 2 Evaluation of hypercalcaemia (calcium > 2.6)
Calcium Low Evaluation of hypocalcaemia (calcium < 2.2)
CK High Causes of an elevated CK (M > 200 F > 140)
Globulin High Evaluation of hyperglobulinaemia (globulins > 44)
Glucose Low Evaluation of hyperglycaemia (plasma glucose < 2.8 mmol/L)
LDI Evaluation of Lactate Dehydrogenase Isoenzymes (LDI)
MI Change Cardiac enzyme changes during myocardial infarction
Magnesium Low Causes of hypomagnesaemia (magnesium < 0.7mmol/L)
Phosphate High Causes of hyperphosphataemia (phosphate > 1.8)
Phosphate Low Causes of hypophosphataemia (mild 0.5~0.65 mmol/L; severe < 0.4 mmol/L)
Polyuria Evaluation of polyuria (urine volume > 3L/24hrs)
Potassium High 1 Causes of hyperkalaemia (potassium > 5.0)
Potassium High 2 Evaluation of hyperkalaemia (potassium > 5.0)
Potassium Low 1 Causes of hypokalaemia (potassium < 3.0)
Potassium Low 2 Evaluation of hypokalaemia (potassium < 3.0)
Sodium Low Causes of hyponatraemia (sodium < 130)
Urate High Evaluation of hyperuricaemia (M > 0.45 F > 0.40)

Immunology

 
Plasma Cell Dys Evaluation of plasma cell dyscrasias
IgM Plasma Cell Dys Evaluation of IgM plasma cell dyscrasias
Coeliac Coeliac disease investigation
IgA Low Evaluation of selective IgA deficiency

Liver Function Tests

ALP High 1 Causes of an Isolated serum Alkaline Phosphatase (ALP) elevation (ALP > 180 IU/L)
ALP High 2 Evaluation of ALP elevation (ALP > 180 IU/L)
ALP High 3 Evaluation of an isolated serum ALP elevation ? growth related (age < 19 yrs)
ALP High 4 Serum ALP elevation ? growth related (age < 19 yrs) - see flowchart
ALP High 5 Marked serum ALP elevation (ALP > 700 IU/L age < 5 yrs)
GGT High Causes of an elevated serum Gamma Glutamyl Transferase (GGT) (GGT > 100 U/L)
LD High Evaluation of an elevated serum Lactate Dehydrogenase (LD) (LD > 300 U/L)
LFT 1 Evaluation of a moderate elevation of aminotransferase levels (AST & ALT)
LFT 2 Predominant hepatocellular pathology (ALT or AST > 150 U/L ALP < 200 U/L)
LFT 3 Evaluation of a LFT pattern not typical of liver disease (elevated LD, AST > ALT)
LFT 4 Causes of an isolated hyperbilirubinaemia (bilirubin > 25 mmol/L)
LFT 5 Evaluation of an isolated hyperbilirubinaemia (bilirubin > 30 mmol/L)
LFT 6 Evaluation of jaundice (ALT < 400 U/L ALP > 350 U/L)
LFT 7 Evaluation of jaundice (ALT > 300 U/L ALP < 350 U/L)
LFT 8 Evaluation of localised cholestasis (ALP > 180 U/L ALT < 150 U/L GGT > 100 U/L bilirubin < 50 umol/L)
LFT 9 Evaluation of mixed hepatocellular and cholestatic disease (ALP > 180 U/L GGT > 65 U/L ALT or AST > 150 U/L)

Microbiology & Patient Notes

Haematuria Causes of isolated microscopic haematuria
Occult blood Faecal occult blood
What is Barmah Forest virus? Symptoms, incubation, treatment and prevention of Barmah Forest virus
What is blastocystosis? Symptoms, infection period, diagnosis, treatment and prevention of blastocystosis
What is cryptosporidiosis? Symptoms, infection period, spread of infection and treatment of cryptosporidiosis
What is giardiasis? Symptoms, infection period, spread of infection, diagnosis, treatment and prevention of giardiasis
What is listeriosis? Symptoms, causes, infection period, diagnosis, treatment and prevention of listeriosis
What is parvovirus? Causes, infection period, spread of infection, diagnosis, treatment and prevention of parvovirus
What is Ross River virus? Symptoms, infection period, spread of infection, diagnosis, treatment and prevention of Ross River virus

Serology

Hep A Serological events in acute (self-limiting) Hepatitis A infection relative to Alanine Aminotransferase (ALT) peak
Hep B 1 Serological events in acute (self-limiting) Hepatitis B infection relative to ALT peak
Hep B 2 Hepatitis B immune status
Pertussis Treatment of Bordetella pertussis

Warfarin Management

Warfarin 1 Range of International Normalised Ratio (INR) recommended for specific applications of warfarin therapy
Warfarin 2 Guidelines to the management of an elevated INR, with or without bleeding
Warfarin 3 Risk factors for bleeding complications of warfarin therapy